Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes

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Low selection of topoisomerase mutants from strains of Escherichia coli harbouring plasmid-borne qnr genes.

OBJECTIVES To investigate mutations in the type II topoisomerase genes in quinolone-resistant mutants selected from bacteria harbouring plasmid-borne qnr genes. METHODS Mutants were selected by nalidixic acid, ciprofloxacin and moxifloxacin from two Escherichia coli reference strains and corresponding transconjugants harbouring qnrA1, qnrA3, qnrB2 or qnrS1 genes. RESULTS The proportion of r...

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INTRODUCTION Plasmid-mediated quinolone resistance, which complicates treatment, has been increasingly identified in Escherichia coli isolates worldwide. The purpose of this study was to identify the plasmid-mediated qnrA and qnrB genes among the quinolone-resistant Escherichia coli isolated from urinary tract infections in Iran. METHODOLOGY A total of 140 Escherichia coli isolates were colle...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2008

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dkn077